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I have been using this brand of CoQ10 for several years. I feel assured I am getting what I need to stay healthy!

joints are feeling better

I am a fan of Dr. Ken Berry and he recommended your CoQ10 because it didn't have any unnecessary ingredients. It seems to be working and I am looking forward to ordering it again. I was a little worried yesterday when I saw you were sold out but this email has reassured me that I will be ordering again. Virginia Williamson


This is great for the body. Every one should be taking this daily is my opinion.

Best CoQ10

I am not only taking NutriGenomic Naturals CoQ10 daily but also have my mother who has heart issues taking it. We are both pleased with the quality and feel it helps our over all health. I would highly recommend it to anyone.

The Best!

This is the best brand of CoEnzyme Q10 out there!

Benefits of CoQ10 Clone copy

17 Benefits of CoQ10 with Clinical Research links ~ 
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1) Increased Energy ​​​​​​​-  CoQ10 plays a critical role in the production of ATP / adenosine triphosphate (energy) within the mitochondria of every cell in the body. ATP is often referred to as the main “energy currency" of the body because it provides the necessary energy for various cellular functions.

Mitochondria are known as the "powerhouses" of the cells, responsible for converting nutrients into usable energy. CoQ10 is present in high concentrations within the mitochondria, particularly in the inner mitochondrial membrane.

CoQ10 assists in the conversion of energy from carbohydrates and fatty acids into ATP through a process called oxidative phosphorylation.  A lack of CoQ10 can cause a reduction in ATP production, resulting in lower energy levels and fatigue.

CoQ10 serves as an electron carrier within the mitochondrial respiratory chain (MRC), where it transports electrons derived from complex I and II to complex III, enabling a continuous supply of electrons that are required for the process of oxidative phosphorylation with the concomitant product of ATP [3] (Figure 1).

2) Heart Health
-​​​​​​​ CoQ10 is the #1 Cardiologist recommended supplement for heart and cardiovascular health, since it’s been clinically proven to help improve blood flow and blood pressure, as well as reduce the risk of arrhythmias and heart failure. Its heart health benefits have been reported extensively in the International Journal of Cardiology. as well as PubMed.

Heart Failure: Several studies have indicated that CoQ10 supplementation may improve symptoms and functional capacity in individuals with heart failure. CoQ10 is involved in energy production within heart cells, and its supplementation has shown potential in enhancing cardiac function and reducing hospitalizations (References: [1] JACC Heart Failure - Coenzyme Q10 in Heart Failure: A Meta-Analysis; [2] European Journal of Heart Failure - Meta-analysis of clinical trials on use of coenzyme Q10 for the adjunctive treatment of chronic heart failure).

Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease).

Statin-Induced Myopathy: Statin medications, commonly prescribed for managing cholesterol, can sometimes cause muscle pain and weakness (myopathy) as a side effect. CoQ10 supplementation has been investigated as a potential strategy to alleviate these statin-induced muscle symptoms,(Reference: [4] Journal of the American College of Cardiology - Effect of Coenzyme Q10 Therapy on Muscle Wasting in Statin Users).

3) Blood Pressure Management: Some research suggests that CoQ10 supplementation may have a modest lowering effect on blood pressure, particularly in individuals with hypertension. CoQ10’s antioxidant and vasodilatory properties are thought to contribute to its potential antihypertensive effects (Reference: [3] Journal of Human Hypertension


4) Anti-inflammatory Effects: CoQ10 has been found to exhibit anti-inflammatory properties in various studies, which can help regulate immune responses and reduce excessive inflammation (Reference: [3] Journal of Clinical & Experimental Cardiology Coenzyme Q10 supplementation reduces inflammatory markers in patients with coronary artery disease).

In a study by Yakin et al. [79 CoQ10 treatment increased the total antioxidant status as well as decreased the levels of TNF and IL-6 (inflammatory cytokines).

CoQ10 may also induce the expression of the transcription factors Nrf2 (nuclear factor erythroid 2-related factor 2), which binds to the antioxidant response element that activates a battery of genes resulting in the expression of antioxidant and detoxifications proteins, in turn resulting in a suppression of the inflammatory response [74].

CoQ10 treatment was found to decrease the production of IL-6 and COX-2 ​​​​​​​ (inflammatory molecules) in the small intestine, as well as increase both the level of GSH and the activity of catalase, in addition to decreasing the level of lipid peroxidation as indicated by malondialdehyde [80]. Interestingly, CoQ10 treatment was found to decrease the expression of intestinal NfkB, which was thought to be directly responsible for the decrease in the levels of IL-6 and COX-2.

5) Immune System:  CoQ10 performs a number of cellular functions of potential relevance to the immune system. Firstly, CoQ10 has a key role in cellular energy supply and the immune response has intensive energy requirements and an adequate supply of CoQ10 is therefore required to enable the various cell types of the immune system to function optimally.

Secondly, CoQ10 is able to directly modulate the action of genes involved in inflammation and may have a role in controlling the release of pro-inflammatory cytokines in disorders where this may be required [6].

Some research suggests that CoQ10 supplementation may have a positive impact on immune response and modulate immune function (Reference: [2] Clinical Immunology - Coenzyme Q10 affects expression of genes involved in cell signaling, metabolism, and transport in human T lymphocytes). This modulation could potentially enhance immune system efficiency.

CoQ10 is required for the optimal function of the immune system, as well as mediating inflammatory response in disease. The functions of CoQ10 supplementation in the treatment of immunopathy and in the immune function of other diseases are outlined in Figure 2. Indeed, the prospect of immune dysfunction has been associated with human CoQ10 deficiency

 Figure 2 image:


Several clinical studies have linked depleted CoQ10 levels to an increased susceptibility to infection. Thus, Chase et al. [25] reported significantly reduced serum CoQ10 levels in patients with influenza compared to healthy control subjects. In children hospitalized with pandemic influenza (H1N1), Kelekçi et al. [26] reported a significant correlation between depletion of serum CoQ10 levels and chest radiographic findings.


In a randomized placebo-controlled clinical trial, elderly patients with pneumonia showed significantly improved recovery following administration of CoQ10 (200 mg/day for 14 days) compared to the placebo group with a shortening of the symptomatic period and duration of treatment being reported [27


Specifically with regard to infection with SARS-CoV-2 virus, in a clinical study by Israel et al. [28], intake of CoQ10 was associated with a significantly reduced risk of hospitalization from SARS-CoV-2. In this large population study, patients hospitalized following SARS-CoV-2 infection were assigned to two case-control cohorts, which differed in the manner in which control subjects were selected—either from the general population or from patients infected with SARS-CoV-2 but not requiring hospitalization. From a range of substances investigated, three were identified which significantly reduced the risk of hospitalization following SARS-CoV-2 infection, most notably the ubiquinone form of CoQ10

Additionally of note is the computational study by Caruso et al. [31], in which the authors identified CoQ10 as a compound capable of inhibiting the SARS-CoV-2 virus, via binding to the active site of the main viral protease (SARS-CoV-2 Mpro protease) which is required for viral replication. In SARS-CoV-2 infections, a balance must be achieved in immune defense against the virus, without precipitating the so-called cytokine storm, the uncontrolled release of pro-inflammatory cytokines responsible for lung injury and respiratory distress in severely affected patients [32].


Folkers and colleagues have reported the ability of CoQ10 monotherapy as well as CoQ10 taken together with vitamin B6 (pyridoxine) to significantly increase the levels of T4-lymphocytes together with the immunoglobulin, IgG in human subjects providing further support for the use of this isoprenoid in the treatment of infectious diseases [33].


In a case report by Farough et al. [40], a 4-year-old child with immune dysfunction (manifested as abnormal T-cell function and frequent recurrent infections) was found to be CoQ10 deficient (via muscle biopsy analysis). Supplementation with CoQ10 (150 mg/day for 12 months) resulted in a significant improvement in T-cell function as measured by the proliferative response with interleukins and reduced incidence of infections. The improvement in immune function was accompanied by a plasma CoQ10 level above the reference range at 3 months and within the reference range at 12 months following supplementation.


supplementation with CoQ10 (200 mg/day for 2 months) resulted in a significant increase in the blood levels of a T-lymphocyte subtype (T4, responsible for immune response regulation) and IgG (the most common type of antibody produced by B-lymphocytes)


CoQ10 may help reduce oxidative stress and protect immune cells from damage (Reference: [1] PubMed Central - Antioxidant role of Coenzyme Q10). Oxidative stress can negatively affect immune function, and by reducing it, CoQ10 may indirectly support a healthy immune system.


Indeed, the prospect of immune dysfunction has been associated with human CoQ10 deficiency [40]. In view of the ability of CoQ10 supplementation to enhance the activity of the immune cells, especially the B and T lymphocytes [14], as well as ameliorate the inflammatory response [47], it may be appropriate for use in a number of diseases of the immune system. One such disease is the neurodegenerative disorder multiple sclerosis (MS), an immune-mediated disease of the central nervous system. A study by Sanoobar et al. [90] reported the ability of CoQ10 supplementation to reduce the circulatory levels of the inflammatory markers (TNF, IL-6, and metallopeptidase 9; MMP-9) in MS patients



6) Cancer prevention:  Interestingly, people with cancer have been shown to have lower levels of CoQ10. Some studies suggest low levels of CoQ10 may be associated with a higher risk of certain types of cancer in some older studies, including breast and prostate cancer (42Trusted Source, 43 Trusted Source, 44

Trusted Source). Several newer studies have also suggested this with regard to lung cancer (45, 46 Trusted Source ).


Evidence of decreased plasma concentrations of CoQ10 has been reported in patients with cancer (breast cancer, myeloma, lymphoma, and lung cancer) [63,64]. Furthermore, Jolliet et al. [65] reported decreased levels of plasma CoQ10 in both patients with breast cancer, and also in patients with non-malignant breast disease. These results indicated that the decreased CoQ10 levels may also be responsible for benign mammary cell growth. The study also found a statistically significant relationship between the plasma CoQ10 level and breast cancer prognosis.


The overexpression of the inflammatory cytokines, IL-6 and TNF have been reported in the tumor microenvironment, where they promote all the hallmarks of cancer, including cell proliferation, angiogenesis, invasiveness, and metastasis [69]. Interestingly, since CoQ10 has been reported to decrease the circulatory level of these cytokines [47], the deficit in CoQ10 status reported in cancer patients may contribute to the high levels of IL-6 and TNF detected in this disease [69,70]. Indeed, a preliminary study in six cancer patients reported the ability of CoQ10 therapy to reduce the circulatory levels of TNF.


Cancer cells have been known for a long time to be able to tame or dampen down the immune system preventing an immune response from being directed at the cancer. However, a CoQ10 derivative known as 4-aetylantroquinonol derived from the mycelium of Antrodia cinnamonea has the potential to improve the anti-tumor immune response, by increasing the antigen-presenting ability of dendritic cells and their ability to secrete immune-related cytokines decreasing the secretion of immune escape related cytokines, IL-6 and IL-10 [81].


Other studies have reported evidence of cancer remission following CoQ10 supplementation [72,73


Increasing impact of chemotherapy drugs and protect from side effects: Supplementing with CoQ10 during cancer treatment may help increase the cancer-killing potential of these medications (like doxorubicin and daunorubicin). There is also evidence that CoQ10 can protect the heart from DNA damage that can sometimes occur from high doses of chemotherapy medications.


May slow or reverse spread of breast cancer: A 2017 article published in Future Oncology states: “Medical approaches are available for treatment of BC… A promising candidate is coenzyme Q10 which is an antioxidant that can target the mechanisms of BC tumor progression.” That’s not all. A 1994 study followed 32 breast cancer patients (ranging from 32–81 years old) classified as “high-risk,” due to the way their cancer had spread to lymph nodes. Each patient was given nutritional antioxidants, essential fatty acids and 90 milligrams per day of CoQ10. Not only did no patients die over the study period of 18 months, but no patient worsened during this period, all reported quality of life improvements and six patients went into partial remission. Two of the patients in partial remission were then given more coenzyme Q10 (300 milligrams each day), both of whom went into total remission, showing complete absences of previous tumors and tumor tissue (one after two months, the other after three months).


    • Could help prevent colon cancer: One research study discovered CoQ10 significantly lowered oxidative stress in the colon that leads to colon cancer.
    • Might play a role in the prevention of cervical cancer: Low levels of CoQ10 are seen in patients with cervical cancer, although it’s not clear why.
    • May improve survival rate in end-stage cancers: A pilot study over nine years followed 41 patients with various primary cancers that had advanced to stage four and were given CoQ10 supplements plus an additional antioxidant mixture. Of the patients followed, the median time of survival was 17 months, five months longer than expected overall. In total, 76 percent of the patients survived longer than expected on average, with little to no side effects noted from the treatment.
    • ​​​​​​​


7) Antioxidant Activity: CoQ10 also acts as an antioxidant, protecting the mitochondria from oxidative damage. As mitochondria generate energy, reactive oxygen species (ROS) are produced as byproducts. Excessive ROS can lead to mitochondrial dysfunction and reduced energy production. CoQ10’s antioxidant properties help neutralize these harmful free radicals, preserving mitochondrial function and supporting energy production. 


CoQ10 functions as an important lipid-soluble antioxidant, protecting cellular membranes and circulatory lipoproteins from free radical-induced oxidative damage [4].



8) Blood sugar:  Abnormal mitochondrial function has also been linked to insulin resistance (36 Trusted Source).

CoQ10 has been suggested to improve insulin sensitivity and regulate blood sugar levels (37 Trusted Source, 38 Trusted Source).



A few studies have suggested that CoQ10 supplementation may have a positive impact on blood sugar control in individuals with type 2 diabetes. One study demonstrated that CoQ10 supplementation improved glycemic control and reduced markers of oxidative stress in participants with type 2 diabetes (Reference: [1] Journal of Clinical Biochemistry and Nutrition - Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with type 2 diabetes mellitus).


Insulin Resistance: CoQ10 has been investigated for its potential role in improving insulin sensitivity and reducing insulin resistance, a hallmark of type 2 diabetes. Some studies have shown modest improvements in insulin resistance markers with CoQ10 supplementation (Reference: [2] European Journal of Clinical Nutrition - The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial).


Another study in people with diabetic neuropathy — a type of nerve damage that can occur in people with diabetes — found that taking 100 mg of CoQ10 daily for 12 weeks may have improved HbA1c levels and insulin resistance (39

Trusted Source). Not only that, but it also may have reduced markers of oxidative stress and harmful compounds, such as advanced glycation end products, compared to a placebo (39 Trusted Source).




9) Brain health: Some research suggests that CoQ10 supplementation may have a positive impact on cognitive function, particularly in older adults. It has been associated with improvements in memory, attention, and executive function, although more robust studies are needed to establish definitive conclusions.


Neuroprotective Effects: CoQ10 has been studied for its potential neuroprotective effects. It may help protect brain cells from damage and improve their resilience against various factors that can contribute to neurodegenerative conditions.


The brain is very susceptible to oxidative damage due to its high fatty acid content and its high demand for oxygen (51Trusted Source). This oxidative damage enhances the production of harmful compounds that can affect memory, cognition, and physical functions (52 Trusted Source).


CoQ10 may help reduce these harmful compounds, possibly slowing the progression of Alzheimer’s and Parkinson’s disease, according to some animal studies (53 Trusted Source, 54

Trusted Source, 55 Trusted Source).


CoQ10 has also been studied for its potential impact on age-related cognitive decline. Some research suggests that CoQ10 supplementation may have a positive effect on certain cognitive measures, such as memory and executive function, in older adults (Reference: [4] Aging Clinical and Experimental Research - The effect of coenzyme Q10 supplementation on cognitive function in elderly individuals: a systematic review)


Some studies have suggested potential benefits of CoQ10 supplementation in certain neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease. These studies indicated improvements in certain symptoms or markers of the disease (References: [1] Journal of Neurochemistry - Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies; [2] Journal of Neural Transmission - Coenzyme Q10 supplementation and cognitive function in individuals aged 40-70 years: a systematic review and meta-analysis).



10) Fertility - Female fertility decreases with age due to a decline in the number and quality of available eggs (13Trusted Source).

CoQ10 is directly involved in this process. As you age, CoQ10 production slows, making the body less effective at protecting the eggs from oxidative damage (14Trusted Source).

Supplementing with CoQ10 seems to help and may even reverse this age-related decline in egg quality and quantity (14

Trusted Source).

Similarly, male sperm is susceptible to oxidative damage, which may result in reduced sperm count, poor sperm quality, and infertility (15Trusted Source).

Several studies have concluded that supplementing with CoQ10 may improve sperm quality, activity, and concentration by increasing antioxidant protection (16

Trusted Source, 17 Trusted Source).



11) Helps Treat Symptoms of Fibromyalgia

Multiple clinical trials and case reports have found that CoQ10 may be a powerful natural method of treating fibromyalgia symptoms. In adults, the dosage was typically 300 milligrams per day, while one study on juvenile fibromyalgia focused on a 100 milligram dose.

Improvements included:


12) Depression and Mood:  Adjunctive Therapy: CoQ10 has been investigated as an adjunctive therapy for individuals with depression who are already receiving standard antidepressant treatment. Some studies have shown modest improvements in depressive symptoms when CoQ10 is used alongside conventional treatment (Reference: [1] Journal of Clinical Psychopharmacology - Coenzyme Q10 as an adjunctive treatment for depression: a randomized, double-blind, placebo-controlled trial).



13) Migraine Prevention: CoQ10 has been investigated for its potential role in preventing migraines, and some studies have shown promising results. These studies suggest that CoQ10 supplementation may reduce the frequency and severity of migraines (Reference: [3] Neurology - Coenzyme Q10 for the preventive treatment of migraines: a systematic review


Abnormal mitochondrial function can lead to increased calcium uptake by the cells, the excessive production of free radicals, and decreased antioxidant protection. This can result in low energy in the brain cells and may contribute to migraine (24

Trusted Source). Since CoQ10 lives mainly in the mitochondria of the cells, it has been shown it may help improve mitochondrial function and may be beneficial for the treatment of migraine (25Trusted Source).


One review of five studies found that CoQ10 may effectively reduce the duration and frequency of migraine in children and adults (26Trusted Source).


Another small study of 80 people found that people taking 100 milligrams (mg) of CoQ10 daily experienced a significant reduction in the frequency, severity, and duration of migraine, with no adverse side effects reported (27Trusted Source).


Lastly, one 2017 study showed that CoQ10 might help reduce the frequency of headaches and make them shorter and less severe (28Trusted Source). 


14) Liver, Kidneys other disorders:

Administration of supplemental CoQ10 has been shown (on the basis of randomized controlled clinical trials) to benefit a number of disorders, especially the prevention [92] or treatment [93] of cardiovascular disease, but also diabetes [94], non-alcoholic fatty liver disease [95], and chronic kidney disease [96], as well as some neurological disorders [97]. In particular, the use of supplemental CoQ10 for the treatment of heart failure has become well-established based on such evidence.



15) Support healthy skin aging: Your skin is the largest organ in your body, and it’s widely exposed to damaging agents that contribute to aging (18Trusted Source). These agents can be internal or external. Some internal damaging factors include cellular damage and hormonal imbalances, while external factors include environmental agents such as UV rays (19). Harmful elements can lead to reduced skin moisture and protection from environmental aggressors, as well as the thinning of the layers of the skin (20 Trusted Source).


According to one 2015 study, applying CoQ10 directly to the skin may reduce the damage from internal and external agents by increasing energy production in skin cells and promoting antioxidant protection (21Trusted Source). When CoQ10 is applied directly to the skin, it may help reduce oxidative damage caused by UV rays and help decrease the depth of wrinkles, according to human and animal studies (22Trusted Source, 23 Trusted Source).



16) Increase exercise performance - CoQ10 may help exercise performance by decreasing oxidative stress in the cells and improving mitochondrial function (32

Trusted Source). One study found that CoQ10 supplementation may have helped inhibit oxidative stress and markers of muscle and liver damage in adolescent elite swimmers during their competition phase (33 Trusted Source). Furthermore, supplementing with CoQ10 may help reduce fatigue, which could also potentially improve exercise performance (34Trusted Source).

​​​​​​​ ​​​​​​​

17) Protect The Lungs: Of all your organs, your lungs have the most contact with oxygen. This makes them very susceptible to oxidative damage. Increased oxidative damage in the lungs and poor antioxidant protection, including low levels of CoQ10, can result in lung diseases, such as chronic obstructive pulmonary disease (COPD) and asthma (56Trusted Source). Some older studies have found that people with these conditions tend to have lower levels of CoQ10 (57 Trusted Source, 58Trusted Source).

A 2005 study demonstrated that supplementing with CoQ10 may have reduced inflammation in individuals who had asthma, as well as their need for steroid medications to treat it (59Trusted Source). Another study found that supplementing with CoQ10 and creatine — a compound found in muscle cells — improved functional performance, perception of shortness of breath, and body composition in people with COPD (60Trusted Source).

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These statements have not been evaluated by the FDA. It is important to note that while these studies indicate benefits from CoQ10 supplementation, individual responses to CoQ10 supplementation may vary. It is always advisable to consult with a healthcare professional before starting any supplement regimen, especially for help in managing any health condition or disease. They can provide personalized guidance based on your specific health needs and considerations.


  1. Koh T.J., DiPietro L.A. Inflammation and wound healing: The role of the macrophage. Expert Rev. Mol. Med. 2011;13:e23. doi: 10.1017/S1462399411001943. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  2. Serhan C.N., Dalli J., Colas R.A., Winkler J.W., Chiang N. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim. et Biophys. Acta (bba)-Mol. Cell Biol. Lipids. 2015;1851:397–413. doi:10.1016/j.bbalip.2014.08.006. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  3. Hargreaves I.P. Ubiquinone: Cholesterol’s reclusive cousin. Ann. Clin. Biochem. 2003;40:207–218. doi:10.1258/000456303321610493. [PubMed] [CrossRef] [Google Scholar]
  4. Crane F.L. Biochemical functions of coenzyme Q10. J. Am. Coll. Nutr. 2001;20:591–598. doi:10.1080/07315724.2001.10719063. [PubMed] [CrossRef] [Google Scholar]
  5. Rosen G.M., Pou S., Ramos C.L., Cohen M.S., Britigan B.E. Free radicals and phagocytic cells. FASEB J. 1995;9:200–209. doi:10.1096/fasebj.9.2.7540156. [PubMed] [CrossRef] [Google Scholar]
  6. Schmelzer C., Lindner I., Rimbach G., Niklowitz P., Menke T., Döring F. Functions of coenzyme Q10 in inflammation and gene expression. Biofactors. 2008;32:179–183. doi:10.1002/biof.5520320121. [PubMed] [CrossRef] [Google Scholar]
  7. Fülöp T., Dupuis G., Witkowski J.M., Larbi A. The role of immunosenescence in the development of age-related diseases. Rev. de Investig. Clin. 2016;68:84–91. [PubMed] [Google Scholar]
  8. Blasco M.A. Immunosenescence phenotypes in the telomerase knockout mouse. Springer Semin. Immunopathol. 2002;24:75–85. doi:10.1007/s00281-001-0096-1. [PubMed] [CrossRef] [Google Scholar]
  9. Maue A.C., Yager E.J., Swain S.L., Woodland D.L., Blackman M.A., Haynes L. T-cell immunosenescence: Lessons learned from mouse models of aging. Trends Immunol. 2009;30:301–305. doi: 10.1016/j.it.2009.04.007. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  10. Heidrick M.L., Makinodan T. Nature of cellular deficiencies in age-related decline of the immune system. Gerontology. 1972;18:305–320. doi:10.1159/000211942. [PubMed] [CrossRef] [Google Scholar]
  11. Segre D., Segre M. Age-related changes in B and T lymphocytes and decline of humoral immune responsiveness in aged mice. Mech. Ageing Dev. 1977;6:115–129. doi:10.1016/0047-6374(77)90013-6. [PubMed] [CrossRef] [Google Scholar]
  12. Bliznakov E.G. Immunological senescence in mice and its reversal by coenzyme Q10. Mech. Ageing Dev. 1978;7:189–197. doi:10.1016/0047-6374(78)90065-9. [PubMed] [CrossRef] [Google Scholar]
  13. Bliznakov E., Watanabe T., Saji S., Folkers K. Coenzyme Q deficiency in aged mice. J. Med. 1978;9:337–346. [PubMed] [Google Scholar]
  14. Tian G., Sawashita J., Kubo H., Nishio S.-Y., Hashimoto S., Suzuki N., Yoshimura H., Tsuruoka M., Wang Y., Liu Y. Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. Antioxid. Redox Signal. 2014;20:2606–2620. doi:10.1089/ars.2013.5406. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  15. Warren J.L., MacIver N.J. Regulation of adaptive immune cells by sirtuins. Front. Endocrinol. 2019;10:466. doi: 10.3389/fendo.2019.00466. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  16. Jhun J., Lee S.H., Byun J.-K., Jeong J.-H., Kim E.-K., Lee J., Jung Y.-O., Shin D., Park S.H., Cho M.-L. Coenzyme Q10 suppresses Th17 cells and osteoclast differentiation and ameliorates experimental autoimmune arthritis mice. Immunol. Lett. 2015;166:92–102. doi: 10.1016/j.imlet.2015.05.012. [PubMed] [CrossRef] [Google Scholar]
  17. Licitra F., Puccio H. An overview of current mouse models recapitulating coenzyme q10 deficiency syndrome. Mol. Syndromol. 2014;5:180–186. doi:10.1159/000362942. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  18. Caobi A., Dutta R.K., Garbinski L.D., Esteban-Lopez M., Ceyhan Y., Andre M., Manevski M., Ojha C.R., Lapierre J., Tiwari S., et al. The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy. Aging Dis. 2020;11:895–915. doi:10.14336/AD.2019.0927. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  19. Cheng W., Song C., Anjum K., Chen M., Li D., Zhou H., Wang W., Chen J. Coenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunity. Int. J. Immunogenet. 2011;38:331–337. doi:10.1111/j.1744-313X.2011.01012.x. [PubMed] [CrossRef] [Google Scholar]
  20. Qiao W., Yu S., Sun H., Chen L., Wang R., Wu X., Goltzman D., Miao D. 1, 25-Dihydroxyvitamin D insufficiency accelerates age-related bone loss by increasing oxidative stress and cell senescence. Am. J. Transl. Res. 2020;12:507. [PMC free article] [PubMed] [Google Scholar]
  21. Kishimoto C., Tomioka N., Nakayama Y., Miyamoto M. Anti-oxidant effects of coenzyme Q10 on experimental viral myocarditis in mice. J. Cardiovasc. Pharmacol. 2003;42:588–592. doi:10.1097/00005344-200311000-00002. [PubMed] [CrossRef] [Google Scholar]
  22. Rousseau G., Varin F. Determination of ubiquinone-9 and 10 levels in rat tissues and blood by high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. Sci. 1998;36:247–252. doi:10.1093/chromsci/36.5.247. [PubMed] [CrossRef] [Google Scholar]
  23. Novoselova E., Safonova M., Gordon R.Y., Semiletova N. Immune functions of spleen lymphocytes of rats subjected to chronic irradiation and antioxidant (ubiquinone Q-9) diet. Int. J. Radiat. Biol. 1995;67:469–476. doi:10.1080/09553009514550541. [PubMed] [CrossRef] [Google Scholar]
  24. Kamzalov S., Sumien N., Forster M.J., Sohal R.S. Coenzyme Q intake elevates the mitochondrial and tissue levels of coenzyme Q and α-tocopherol in young mice. J. Nutr. 2003;133:3175–3180. doi:10.1093/jn/133.10.3175. [PubMed] [CrossRef] [Google Scholar]
  25. Chase M., Cocchi M.N., Liu X., Andersen L.W., Holmberg M.J., Donnino M.W. Coenzyme Q10 in acute influenza. Influenza Other Respir. Viruses. 2019;13:64–70. doi:10.1111/irv.12608. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  26. Kelekçi S., Evliyaoğlu O., Sen V., Yolbaş I., Uluca U., Tan I., Gürkan M. The relationships between clinical outcome and the levels of total antioxidant capacity (TAC) and coenzyme Q (CoQ 10) in children with pandemic influenza (H 1 N1) and seasonal flu. Eur. Rev. Med. Pharmacol. Sci. 2012;16:1033–1038. [PubMed] [Google Scholar]
  27. Farazi A., Sofian M., Jabbariasl M., Nayebzadeh B. Coenzyme Q10 administration in community-acquired pneumonia in the elderly. Iran. Red Crescent Med. J. 2014;16:e18852. doi: 10.5812/ircmj.18852. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  28. Israel A., Schäffer A.A., Cicurel A., Feldhamer I., Tal A., Cheng K., Sinha S., Schiff E., Lavie G., Ruppin E. Large population study identifies drugs associated with reduced COVID-19 severity. MedRxiv. 2020 doi: 10.1101/2020.10.13.20211953. [CrossRef] [Google Scholar]
  29. Ayala D.J.M.-F., Navas P., López-Lluch G. Age-related mitochondrial dysfunction as a key factor in COVID-19 disease. Exp. Gerontol. 2020:111147. doi: 10.1016/j.exger.2020.111147. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  30. Gvozdjakova A., Klauco F., Kucharska J., Sumbalova Z. Is mitochondrial bioenergetics and coenzyme Q10 the target of a virus causing COVID-19? Bratisl. Lek. Listy. 2020;121:775–778. doi:10.4149/BLL_2020_126. [PubMed] [CrossRef] [Google Scholar]
  31. Caruso F., Rossi M., Pedersen J.Z., Incerpi S. Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone. J. Infect. Public Health. 2020;13:1868–1877. doi: 10.1016/j.jiph.2020.09.015. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  32. Hu B., Huang S., Yin L. The cytokine storm and COVID-19. J. Med. Virol. 2021;93:250–256. doi:10.1002/jmv.26232. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  33. Folkers K., Morita M., McRee J. The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem. Biophys. Res. Commun. 1993;193:88–92. doi:10.1006/bbrc.1993.1593. [PubMed] [CrossRef] [Google Scholar]
  34. Simpson R.J., Kunz H., Agha N., Graff R. Exercise and the regulation of immune functions. Prog. Mol. Biol. Transl. Sci. 2015;135:355–380. [PubMed] [Google Scholar]
  35. Emami A. The Impact of Pre-Cooling and CoQ10 Supplementation on Mediators of Inflammatory Cytokines in Elite Swimmers. Nutr. Cancer. 2020;72:41–51. doi:10.1080/01635581.2019.1614200. [PubMed] [CrossRef] [Google Scholar]
  36. Shimizu K., Kon M., Tanimura Y., Hanaoka Y., Kimura F., Akama T., Kono I. Coenzyme Q10 supplementation downregulates the increase of monocytes expressing toll-like receptor 4 in response to 6-day intensive training in kendo athletes. Appl. Physiol. Nutr. Metab. 2015;40:575–581. doi:10.1139/apnm-2014-0556. [PubMed] [CrossRef] [Google Scholar]
  37. Trushina E.N., Vybornov V.D., Riger N.A., Mustafina O.K., Solntseva T.N., Timonin A.N., Zilova I.S., Rajabkadiev R.M. Immunomodulating effects of using L-carnitine and coenzyme Q(10) in the nutrition of junior athletes. Vopr. Pitan. 2019;88:40–49. doi:10.24411/0042-8833-2019-10016. [PubMed] [CrossRef] [Google Scholar]
  38. Brauner H., Lüthje P., Grünler J., Ekberg N., Dallner G., Brismar K., Brauner A. Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q 10 on inflammatory activity. Clin. Exp. Immunol. 2014;177:478–482. doi:10.1111/cei.12316. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  39. Barbieri B., Lund B., Lundström B., Scaglione F. Coenzyme Q10 administration increases antibody titer in hepatitis B vaccinated volunteers—A single blind placebo-controlled and randomized clinical study. Biofactors. 1999;9:351–357. doi:10.1002/biof.5520090235. [PubMed] [CrossRef] [Google Scholar]
  40. Farough S., Karaa A., Walker M., Slate N., Dasu T., Verbsky J., Fusunyan R., Canapari C., Kinane T., Van Cleave J. Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases. Clin. Immunol. 2014;155:209–212. doi:10.1016/j.clim.2014.09.010. [PubMed] [CrossRef] [Google Scholar]
  41. Zhai J., Bo Y., Lu Y., Liu C., Zhang L. Effects of coenzyme Q10 on markers of inflammation: A systematic review and meta-analysis. PLoS ONE. 2017;12:e0170172. [PMC free article] [PubMed] [Google Scholar]
  42. Barden A.E., Shinde S., Burke V., Puddey I.B., Beilin L.J., Irish A.B., Watts G.F., Mori T.A. The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney disease. Prostaglandins Other Lipid Mediat. 2018;136:1–8. doi:10.1016/j.prostaglandins.2018.03.002. [PubMed] [CrossRef] [Google Scholar]
  43. Farsi F., Mohammadshahi M., Alavinejad P., Rezazadeh A., Zarei M., Engali K.A. Functions of coenzyme Q10 supplementation on liver enzymes, markers of systemic inflammation, and adipokines in patients affected by nonalcoholic fatty liver disease: A double-blind, placebo-controlled, randomized clinical trial. J. Am. Coll. Nutr. 2016;35:346–353. doi:10.1080/07315724.2015.1021057. [PubMed] [CrossRef] [Google Scholar]
  44. Lee B.-J., Tseng Y.-F., Yen C.-H., Lin P.-T. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: A randomized, placebo-controlled trial. Nutr. J. 2013;12:142. doi: 10.1186/1475-2891-12-142. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  45. Rahmani E., Jamilian M., Samimi M., Zarezade Mehrizi M., Aghadavod E., Akbari E., Tamtaji O.R., Asemi Z. The effects of coenzyme Q10 supplementation on gene expression related to insulin, lipid and inflammation in patients with polycystic ovary syndrome. Gynecol. Endocrinol. 2018;34:217–222. doi: 10.1080/09513590.2017.1381680. [PubMed] [CrossRef] [Google Scholar]
  46. Alehagen U., Alexander J., Aaseth J., Larsson A. Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: A subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK. J. Inflamm. 2019;16:1–9. doi:10.1186/s12950-019-0210-6. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  47. Fan L., Feng Y., Chen G.-C., Qin L.-Q., Fu C.-l., Chen L.-H. Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacol. Res. 2017;119:128–136. doi:10.1016/j.phrs.2017.01.032. [PubMed] [CrossRef] [Google Scholar]
  48. Mohanty A., Tiwari-Pandey R., Pandey N.R. Mitochondria: The indispensable players in innate immunity and guardians of the inflammatory response. J. Cell Commun. Signal. 2019;13:303–318. doi:10.1007/s12079-019-00507-9. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  49. Vazquez C., Horner S.M. MAVS coordination of antiviral innate immunity. J. Virol. 2015;89:6974–6977. doi:10.1128/JVI.01918-14. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  50. West A.P., Shadel G.S., Ghosh S. Mitochondria in innate immune responses. Nat. Rev. Immunol. 2011;11:389–402. doi:10.1038/nri2975. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  51. Hsing L.C., Rudensky A.Y. The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol. Rev. 2005;207:229–241. doi:10.1111/j.0105-2896.2005.00310.x. [PubMed] [CrossRef] [Google Scholar]
  52. Schmid D., Münz C. Immune surveillance of intracellular pathogens via autophagy. Cell Death Differ. 2005;12:1519–1527. doi:10.1038/sj.cdd.4401727. [PubMed] [CrossRef] [Google Scholar]
  53. Radoja S., Frey A.B., Vukmanovic S. T-cell receptor signaling events triggering granule exocytosis. Crit. Rev. Immunol. 2006;26:265–290. doi:10.1615/CritRevImmunol.v26.i3.40. [PubMed] [CrossRef] [Google Scholar]
  54. Castaneda J.A., Lim M.J., Cooper J.D., Pearce D.A. Immune system irregularities in lysosomal storage disorders. Acta Neuropathol. 2008;115:159–174. doi:10.1007/s00401-007-0296-4. [PubMed] [CrossRef] [Google Scholar]
  55. Mindell J.A. Lysosomal acidification mechanisms. Annu. Rev. Physiol. 2012;74:69–86. doi:10.1146/annurev-physiol-012110-142317. [PubMed] [CrossRef] [Google Scholar]
  56. Gille L., Nohl H. The existence of a lysosomal redox chain and the role of ubiquinone. Arch. Biochem. Biophys. 2000;375:347–354. doi:10.1006/abbi.1999.1649. [PubMed] [CrossRef] [Google Scholar]
  57. Heaton R.A., Heales S., Rahman K., Sexton D.W., Hargreaves I. The Effect of Cellular Coenzyme Q(10) Deficiency on Lysosomal Acidification. J. Clin. Med. 2020;9:1923. doi: 10.3390/jcm9061923. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  58. Ghosh S., Dellibovi-Ragheb T.A., Kerviel A., Pak E., Qiu Q., Fisher M., Takvorian P.M., Bleck C., Hsu V., Fehr A.R. β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway. Cell. 2020;183:1520–1535. doi:10.1016/j.cell.2020.10.039. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  59. Di Cara F., Sheshachalam A., Braverman N.E., Rachubinski R.A., Simmonds A.J. Peroxisome-mediated metabolism is required for immune response to microbial infection. Immunity. 2017;47:93–106.e107. doi:10.1016/j.immuni.2017.06.016. [PubMed] [CrossRef] [Google Scholar]
  60. Odendall C., Dixit E., Stavru F., Bierne H., Franz K.M., Durbin A.F., Boulant S., Gehrke L., Cossart P., Kagan J.C. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat. Immunol. 2014;15:717. doi: 10.1038/ni.2915. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  61. Crane F.L., Sun I.L., Sun E., Morré D.J. Alternative functions for coenzyme Q in endomembranes. In: Folkers K., Littarru G.P., Yamagami T., editors. Biomedical and Clinical Aspects of Coenzyme Q. Elsevier Science Publishers; Amsterdam, The Netherlands: 1991. pp. 59–70. [Google Scholar]
  62. Tekle M., Bentinger M., Nordman T., Appelkvist E.-L., Chojnacki T., Olsson J.M. Ubiquinone biosynthesis in rat liver peroxisomes. Biochem. Biophys. Res. Commun. 2002;291:1128–1133. doi:10.1006/bbrc.2002.6537. [PubMed] [CrossRef] [Google Scholar]
  63. Folkers K., Osterborg A., Nylander M., Morita M., Mellstedt H. Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. Biochem. Biophys. Res. Commun. 1997;234:296–299. doi:10.1006/bbrc.1997.6522. [PubMed] [CrossRef] [Google Scholar]
  64. Folkers K. Relevance of the Biosynthesis of Coenzyme Q10 and of the Four Bases of DNA as a Rationale for the Molecular Causes of Cancer and a Therapy. Biochem. Biophys. Res. Commun. 1996;224:358–361. doi:10.1006/bbrc.1996.1033. [PubMed] [CrossRef] [Google Scholar]
  65. Jolliet P., Simon N., Barre J., Pons J., Boukef M., Paniel B., Tillement J. Plasma coenzyme Q10 concentrations in breast cancer: Prognosis and therapeutic consequences. Int. J. Clin. Pharmacol. Ther. 1998;36:506–509. [PubMed] [Google Scholar]
  66. Chai W., Cooney R.V., Franke A.A., Caberto C.P., Wilkens L.R., Le Marchand L., Goodman M.T., Henderson B.E., Kolonel L.N. Plasma coenzyme Q10 levels and prostate cancer risk: The multiethnic cohort study. Cancer Epidemiol. Prev. Biomark. 2011;20:708–710. doi:10.1158/1055-9965.EPI-10-1309. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  67. Reichenbach J., Schubert R., Schwan C., Zielen S. Antioxidative Capacity in Patients with CommonVariable Immunodeficiency. J. Clin. Immunol. 2000;20:221–226. doi:10.1023/A:1006645731813. [PubMed] [CrossRef] [Google Scholar]
  68. Littarru G., Lippa S., Oradei A., Fiorni R., Mazzanti L. Metabolic and diagnostic implications of blood CoQ10 levels. Biomed. Clin. Asp. Coenzyme Q. 1991;6:167–178. [Google Scholar]
  69. Kumari N., Dwarakanath B., Das A., Bhatt A.N. Role of interleukin-6 in cancer progression and therapeutic resistance. Tumor Biol. 2016;37:11553–11572. doi:10.1007/s13277-016-5098-7. [PubMed] [CrossRef] [Google Scholar]
  70. Balkwill F. Tumour necrosis factor and cancer. Nat. Rev. Cancer. 2009;9:361–371. doi:10.1038/nrc2628. [PubMed] [CrossRef] [Google Scholar]
  71. Hodges S., Hertz N., Lockwood K., Lister R. CoQ10: Could it have a role in cancer management? Biofactors. 1999;9:365–370. doi:10.1002/biof.5520090237. [PubMed] [CrossRef] [Google Scholar]
  72. Folkers K., Brown R., Judy W.V., Morita M. Survival of cancer patients on therapy with coenzyme Q10. Biochem. Biophys. Res. Commun. 1993;192:241–245. doi: 10.1006/bbrc.1993.1405. [PubMed] [CrossRef] [Google Scholar]
  73. Lockwood K., Moesgaard S., Folkers K. Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. Biochem. Biophys. Res. Commun. 1994;199:1504–1508. doi:10.1006/bbrc.1994.1401. [PubMed] [CrossRef] [Google Scholar]
  74. Yang H.-L., Lin M.-W., Korivi M., Wu J.-J., Liao C.-H., Chang C.-T., Liao J.-W., Hseu Y.-C. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim. et Biophys. Acta (bba)-Gene Regul. Mech. 2016;1859:246–261. doi: 10.1016/j.bbagrm.2015.11.001. [PubMed] [CrossRef] [Google Scholar]
  75. Vetvicka V., Vetvickova J. Combination therapy with glucan and coenzyme Q10 in murine experimental autoimmune disease and cancer. Anticancer Res. 2018;38:3291–3297. doi:10.21873/anticanres.12594. [PubMed] [CrossRef] [Google Scholar]
  76. Iarussi D., Auricchio U., Agretto A., Murano A., Giuliano M., Casale F., Indolfi P., Iacono A. Protective effect of coenzyme Q10 on anthracyclines cardiotoxicity: Control study in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma. Mol. Asp. Med. 1994;15:s207–s212. doi:10.1016/0098-2997(94)90030-2. [PubMed] [CrossRef] [Google Scholar]
  77. Judy W., Hall J., Dugan W., Toth P., Folkers K. Coenzyme Q10 reduction of adriamycin cardiotoxicity. Biomed. Clin. Asp. Coenzyme Q. 1984;4:231–241. [Google Scholar]
  78. Beyer R., Ernster L. The Antioxidant Role of Coenzyme Q. Taylor and Francis; London, UK: 1990. pp. 191–213. [Google Scholar]
  79. Yakin M., Eksioglu U., Sadic M., Koca G., Ozkan-Uney G., Yumusak N., Husniye Telek H., Demir A., Yazihan N., Ornek F. Coenzyme Q10 for the protection of lacrimal gland against high-dose radioiodine therapy-associated oxidative damage: Histopathologic and tissue cytokine level assessments in an animal model. Curr. Eye Res. 2017;42:1590–1596. doi:10.1080/02713683.2017.1362006. [PubMed] [CrossRef] [Google Scholar]
  80. Mohamed H.A., Said R.S. Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-β/MMP-9 pathways. Int. Immunopharmacol. 2021;92:107347. doi: 10.1016/j.intimp.2020.107347. [PubMed] [CrossRef] [Google Scholar]
  81. Li T.-Y., Chiang B.-H. 4-Acetylantroquinonol B from Antrodia cinnamomea enhances immune function of dendritic cells against liver cancer stem cells. Biomed. Pharmacother. 2019;109:2262–2269. doi:10.1016/j.biopha.2018.11.101. [PubMed] [CrossRef] [Google Scholar]
  82. Molyneux S.L., Young J.M., Florkowski C.M., Lever M., George P.M. Coenzyme Q10: Is there a clinical role and a case for measurement? Clin. Biochem. Rev. 2008;29:71. [PMC free article] [PubMed] [Google Scholar]
  83. Yubero D., Montero R., Artuch R., Land J.M., Heales S.J., Hargreaves I.P. Biochemical diagnosis of coenzyme Q10 deficiency. Mol. Syndromol. 2014;5:147–155. doi:10.1159/000362390. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  84. Shults C.W., Beal M.F., Song D., Fontaine D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp. Neurol. 2004;188:491–494. doi: 10.1016/j.expneurol.2004.05.003. [PubMed] [CrossRef] [Google Scholar]
  85. Hidaka T., Fujii K., Funahashi I., Fukutomi N., Hosoe K. Safety assessment of coenzyme Q10 (CoQ10) Biofactors. 2008;32:199–208. doi:10.1002/biof.5520320124. [PubMed] [CrossRef] [Google Scholar]
  86. López-Lluch G., del Pozo-Cruz J., Sánchez-Cuesta A., Cortés-Rodríguez A.B., Navas P. Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition. 2019;57:133–140. doi:10.1016/j.nut.2018.05.020. [PubMed] [CrossRef] [Google Scholar]
  87. Bhagavan H.N., Chopra R.K. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007;7:S78–S88. doi:10.1016/j.mito.2007.03.003. [PubMed] [CrossRef] [Google Scholar]
  88. Miles M.V., Patterson B.J., Schapiro M.B., Hickey F.J., Chalfonte-Evans M., Horn P.S., Hotze S.L. Coenzyme Q10 absorption and tolerance in children with Down syndrome: A dose-ranging trial. Pediatric Neurol. 2006;35:30–37. doi:10.1016/j.pediatrneurol.2005.11.004. [PubMed] [CrossRef] [Google Scholar]
  89. Kaikkonen J., Nyyssönen K., Tomasi A., Iannone A., Tuomainen T.-P., Porkkala-Sarataho E., Salonen J.T. Antioxidative efficacy of parallel and combined supplementation with coenzyme Q10 and d-α-tocopherol in mildly hypercholesterolemic subjects: A randomized placebo-controlled clinical study. Free Radic. Res. 2000;33:329–340. doi:10.1080/10715760000301501. [PubMed] [CrossRef] [Google Scholar]
  90. Sanoobar M., Eghtesadi S., Azimi A., Khalili M., Khodadadi B., Jazayeri S., Gohari M.R., Aryaeian N. Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: A double blind, placebo, controlled randomized clinical trial. Nutr. Neurosci. 2015;18:169–176. doi:10.1179/1476830513Y.0000000106. [PubMed] [CrossRef] [Google Scholar]
  91. Wainwright L., Hargreaves I.P., Georgian A.R., Turner C., Dalton R.N., Abbott N.J., Heales S.J., Preston J.E. CoQ10 Deficient Endothelial Cell Culture Model for the Investigation of CoQ10 Blood–Brain Barrier Transport. J. Clin. Med. 2020;9:3236. doi:10.3390/jcm9103236. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  92. Alehagen U., Johansson P., Björnstedt M., Rosén A., Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int. J. Cardiol. 2013;167:1860–1866. doi:10.1016/j.ijcard.2012.04.156. [PubMed] [CrossRef] [Google Scholar]
  93. Mortensen S.A., Rosenfeldt F., Kumar A., Dolliner P., Filipiak K.J., Pella D., Alehagen U., Steurer G., Littarru G.P., Investigators Q.-S.S. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: Results from Q-SYMBIO: A randomized double-blind trial. JACC Heart Fail. 2014;2:641–649. doi:10.1016/j.jchf.2014.06.008. [PubMed] [CrossRef] [Google Scholar]
  94. Mantle D. Coenzyme Q10 supplementation for diabetes and its complications: An overview. Br. J. Diabetes. 2017;17:145–148. doi:10.15277/bjd.2017.149. [CrossRef] [Google Scholar]
  95. Mantle D., Hargreaves I.P. Coenzyme Q10 supplementation in non-alcoholic fatty liver disease: An overview. J. Prescr. Pract. 2020;2:200–204. doi:10.12968/jprp.2020.2.4.200. [CrossRef] [Google Scholar]
  96. Hargreaves I., Mantle D., Milford D. Chronic kidney disease and coenzyme Q10 supplementation. J. Kidney Care. 2019;4:82–90. doi:10.12968/jokc.2019.4.2.82. [CrossRef] [Google Scholar]
  97. Mantle D., Hargreaves I.P. Ataxia and coenzyme Q10: An overview. Br. J. Neurosci. Nurs. 2018;14:108–114. doi:10.12968/bjnn.2018.14.3.108. [CrossRef] [Google Scholar]
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